Nutrigenetics and Nutrigenomics

Nutrigenetics and nutrigenomics study how our genetic constitution affects the response to nutrients and how nutrients affect the expression of genes. We are interested particularly in understanding the interactions between genes and fatty acids (especially polyunsaturated fatty acids), a major dietary nutrient linked to many human diseases. We are utilizing methods of lipidomics and genetics or proteomics to map the relationship between lipid profile and gene expression in tissues from animal models or patients with various diseases, aiming to identify lipid biomarkers of normal biological processes, pathogenic processes or pharmacologic responses to a therapeutic intervention.

Selected Publications:

1. Hudert C, Weylandt KH, Wang J, Lu Y, Song H, Dignass A, Serhan CN, Kang JX.  Fat-1 transgenic mice are protected from experimental colitis. Proc. Natl. Acad. Sci. USA 2006;103(30):11276-11281.
2. Xia SH, Wang J, Lu Y, Song H, Serhan CN and Kang JX. The growth of melanoma is reduced in Fat-1 transgenic mice: Impact of n-6/n-3 essential fatty acids.Proc Natl Acad Sci USA.2006;103:12499-12504.
   
   

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